منابع مشابه
Viewpoint: untoward effects of beta-adrenoceptor agonists in asthma.
Beta-adrenoceptor agonists are potent and selective relaxants of airway smooth muscle. They produce symptomatic bronchodilatory effects and are the most widely used therapy in asthma. In patients with asthma, they usually effect a reduction of airway resistance, but there have been several reports of episodes of increased airway obstruction, arterial hypoxaemia and even death associated with su...
متن کاملSUPPRESSION OF VLDL-TRIACYLGLYCEROL SECRETION B Y BOTH α AND β-ADRENOCEPTOR AGONISTS IN ISOLATED RAT HEPATOCYTES
The effects of alpha and beta-adrenergic stimulation on triacylglycerol secretion were investigated in isolated rat hepatocytes. Epinephrine within 3h of incubation suppressed triacylglycerol secretion by 35% and increased its cellular content by 18%. The inhibitory effect of epinephrine was abolished by inclusion of phentolamine and also prazosin but not with propranolol. Trifluoperazine c...
متن کاملPrescribing of β-adrenoceptor antagonists in asthma: an observational study.
BACKGROUND β-Antagonists have recently been proposed for the treatment of chronic asthma; however, concerns regarding risk of acute bronchoconstriction in clinical trials remain. OBJECTIVE To determine the frequency of oral β-blocker prescribing in patients with asthma and associations with severe asthma exacerbations requiring oral steroids in patients with active asthma defined by prior ast...
متن کاملSafety of long-acting β-agonists in asthma.
in asthma The study by Wolfe et al certainly does not support our claim that serious asthma exacerbations are more frequent in patients receiving formoterol 24 μg twice daily than in those receiving 12 μg twice daily, or placebo. Actually, this statement should have been based on the review by Mann et al, that assessed data from three prospective, randomised, placebo-controlled and double-blind...
متن کاملLong-acting beta 2-adrenoceptor agonists: a new perspective in the treatment of asthma.
New long-acting beta 2-adrenoceptor agonists, formoterol and salmeterol, may soon appear in several European countries for treatment of asthma. This review examines currently available information and compares the basic pharmacology and describes the clinical effects of these new drugs. The long duration of bronchodilation seen in clinical studies seems to be similar, whereas in isolated tissue...
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ژورنال
عنوان ژورنال: Current Opinion in Pharmacology
سال: 2010
ISSN: 1471-4892
DOI: 10.1016/j.coph.2010.03.002